A Case of 18-Year-Old Female with Nasopharyngeal Diffuse Large B Cell Lymphoma / 대한이비인후과학회지

Malignant lymphoma is tumor of the immune system. It is mainly found in the lymph node but it can also originate from extranodal organs such as gastrointestinal tract, sinonasal tract, and etc. We experienced a case of 18-year-old female patient with a huge nasopharyngeal mass. The patient visited our clinic with complaints of nasal obstruction and mouth breathing without general symptoms. After extirpation and biopsy of the nasopharyngeal mass, lesion was diagnosed as malignant lymphoma. In immunohistochemistry, CD 20, Bcl-2, Bcl-6 were positive. Final diagnosis was diffused large B cell lymphoma, for which she received chemotherapy (Rituximab, Cyclophosp, Ahamide, Adriamycin, Vincristine, Prednisone). We report a case of huge malignant lymphoma that occurred in the nasopharynx with a brief review of literature.

Should the High Septal Deviation be Corrected to Improve Nasal Obstruction During Septal Surgery?

BACKGROUND AND OBJECTIVES: High dorsal deflection of the nasal septum around cartilage or the perpendicular plate is technically difficult to correct. The objective of this study was to assess whether correction of high septal deviation during septoplasty is necessary to improve nasal airflow. PATIENTS AND SURGICAL METHOD: Twenty-one patients with high septal deviation around the septal cartilage or the perpendicular plate were included in this study. In order to improve nasal obstruction, septoturbinoplasty was performed, but high septal deviation was not corrected. Subjective and objective improvements were evaluated using the visual analogue scale and acoustic rhinometry 1 month before and 3 months after surgery. RESULTS: After correction of nasal septum deviation except high septal deviation and reduction of turbinate mucosal volume, postoperative nasal volume and minimum cross-sectional area were significantly increased. Subjective symptom scales for nasal obstruction, rhinorrhea, sneezing, and posterior nasal drip were considerably improved after limited septoturbinoplasty in patients who still had high dorsal deflection of the nasal septum. CONCLUSION: Our findings suggest that limited septoturbinoplasty without excessive resection of high dorsal deflection of the nasal septum can improve nasal airflow and reduce subjective symptoms, including nasal obstruction.

Clinical features of respiratory adenovirus infections in pediatric inpatients in a single medical center

PURPOSE: The purpose of this study is to identify the epidemiologic and clinical characteristics of respiratory adenovirus infections in children, and to investigate the difference in the clinical features between single adenovirus infection and coinfection with adenovirus and other respiratory viruses. METHODS: A retrospective study was performed in 470 children hospitalized with respiratory adenovirus infections in Gwangmyeong Sungae Hospital between January 2013 and December 2013. RESULTS: The mean age of the patients was 46.2 months and the peak incidence was in the 12- to 24-month age group. The mean duration of hospitalization and fever were 4.5+/-1.1 and 4.5+/-9.2 days, respectively. Seasonally it had occurred throughout the year, but showed the highest prevalence in August and high prevalence in July, September, and October. The frequency of viral coinfection with other respiratory viruses was 39.6%. The age was significantly younger in coinfection group than in the single adenovirus infection group (P<0.001). The prevalence rates of bronchiolitis (P<0.001) and pneumonia (P=0.042) were significantly higher in the respiratory syncytial virus coinfection group. The coinfection rate was significantly higher in children aged less than 2 years (P<0.001), and the prevalence rates of bronchiolitis (P<0.001) and pneumonia (P<0.001) were also higher in the group aged less than 2 years than other age groups. CONCLUSION: Adenovirus is an important viral agent in hospitalized children with acute respiratory tract infection. Lower respiratory tract infections, such as bronchiolitis and pneumonia, and coinfection with other respiratory viruses were more frequently occurred in patients under 2 years of age. Further studies are needed to clarify whether coinfection with other respiratory viruses would increase the rate of lower respiratory tract infections in patients with respiratory adenoviral infections.

Association between work-related health problems and job insecurity in permanent and temporary employees

OBJECTIVES: This research was conducted with an aim of determining the correlation between job insecurity and an employee's work-related health problems among permanent and temporary workers. METHODS: Using the data from the First Korean Working Conditions Survey conducted in 2006, a total of 7,071 workers, excluding employers and the self-employed, were analyzed. Work-related health problems were categorized as backache, headache, abdominal pain, muscular pain, stress, fatigue, insomnia, anxiety or depression. Each problem was then analyzed for its relationship to job insecurity through logistic regression analysis. RESULTS: Among the 7,071 workers, 5,294 (74.9%) were permanent workers and 1,777 (25.1%) were temporary workers. For the permanent workers, presence of high or moderate job insecurity appeared more closely linked to backache, headache, abdominal pain, muscular pain, stress, fatigue, insomnia, anxiety, and depression compared to absence of job insecurity. However, for the temporary workers, only depression appeared to be associated with the presence of high job insecurity. CONCLUSION: The study showed that the presence of job insecurity is correlated with work-related health problems. The deleterious effects of job insecurity appeared to be stronger in permanent than temporary workers. Additional research should investigate ways to effectively reduce job insecurity.

The Effects of Aircraft Noise Exposure upon Hearing Loss, Anxiety, and Depression on Subjects Residing Adjacent to a Military Airbase / 대한산업의학회지

OBJECTIVES: To determine the level of aircraft noise exposure and how it relates to hearing loss, and to investigate the association between noise exposure and anxiety and depression in subjects residing adjacent to a military airbase. METHODS: The study was conducted upon 898 inhabitants between the ages of 30-79, living near the military airbase in Jeonra-do. The subjects were divided into three noise-exposure groups: high-exposure, low-exposure, and a control group. The cut-values were 80 and 60 on the Weighted Equivalent Continuous Perceived Noise Level scale. A self-administered questionnaire including the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory (BDI) were completed. Pure tone audiometry tests were performed. RESULTS: Hearing loss prevalence was defined by a >40 dB loss in bilateral ears or in one ear; the difference of or =22 was 317 (35.3%), with BDIs > or =21 was 347 (38.6%). The pure tone average, BAI, and BDI scores were higher in the noise-exposure groups compared to the control. The BAI/BDI abnormal subjects showed a higher hearing threshold shift level compared to the normal scored subjects. The odd ratios for anxiety was significantly high in both noise exposure groups and the hearing loss, for depression was significantly high in high-exposure group and hearing loss. CONCLUSIONS: Anxiety and depression were higher when exposure to high-level noise and further complicated by hearing loss. Further investigation is needed to determine the cause-effect relationship.

Study of Exchange Phenomenon of Mycoplasma pneumoniae in Children from 1997-2002 / 소아과

PURPOSE: Mycoplasma pneumoniae(M. pneumoniae) is classified into two groups(I and II) by difference of DNA sequences in P1 protein. Between these two groups, there are some different immune responses and disease severity. M. pneumoniae pneumonia have epidemic outbreaks occurring every three to seven years and these outbreaks are related with rising of either group I or II. We studied cases of M. pneumoniae pneumonia during the past six years(November 1996-October 2002), to evaluate the prevalence and yearly distribution of each group. METHODS: We enrolled 504 patients out of 547 patients, who were admitted to the Department of Pediatrics, Sung-Ae and Kwangmyung Sung-Ae General Hospital from November 1996 to October 2002. They were diagnosed as M. pneumoniae pneumonia by clinical characteristics and indirect particle agglutination test of M. pneumoniae. To classify into two groups, the group specific polymerase chain reaction amplification were performed using specific oligonucleotide primers designed for P1 gene genotyping. RESULTS: Group I(91.7%) occured more frequently than group II(8.3%) during the study period. There were outbreaks of M. pneumoniae pneumonia in 1997 and 2000, which showed epidemics of M. pneumoniae pneumonia were occuring every three or four years, but there was no exchange phenomenon between the two groups. CONCLUSION: Group I was more prevalent than group II with a three years cycle of epidemic outbreak from 1997 to 2002 in Korea. But, six years of research is a relatively short time to compare immune responses, disease severity and exchange phenomenon between the two groups. Further follow-up study will be needed for the epidemiologic and clinical studies of M. pneumoniae in Korea.

A Case of Villous Adenoma with Depletion Syndrome / 대한소화기내시경학회지

Massive secretory diarrhea with pre-renal insufficiency, hyponatremia, hypokalemia and metabolic alkalosis or acidosis is associated with some large villous adenomas of the rectum and is called with depletion syndrome. This characteristic fluid and electrolyte depletion syndrome is caused by secretion of sodium, potassium, and fluid from the tumor. PGE2 formation in the villous adenoma appears to be the cause of fluid secretion by the abnormal tumor epithelium. Surgical removal of villous adenoma is the only promising therapy, In case of inoperability, denial of surgical intervention or just for palliative treatment prior to surgery, the use of PG synthetase inhibitors may facilitate the correction of severe fluid-electrolyte deficits. We reported a case of large villous adenoma of the rectum with depletion syndrome aceompanied by secretory diarrhea and fluid and electrolyte depletion with metabolic alkalosis due to severe vomiting.

Castleman's Disease in Pelvic Cavity / 대한산부인과학회잡지

Castlemans disease is a relatively rare disease of differential diagnostic interest in patients with lymphadenopathy. The etilogy and pathogenesis are still not elucidated. One case of Castlemsns disease of the pelvis is reported. Tumoral lesion was located in the lymph nodes of the right broad ligament. Histologically, the lymph nodes demonstrated the the hyaline-vascular type of Castleman's disease which had a favorable prognosis. This unusal presentation made Castlemans disease difficult to diagnose preoperatively. We describe a patient with Castleman disease of hyaline-vascular type localized to the pelvic cavity.

Clinical significance of Urinary Epidermal Growth Factor in Gynecologic Tumors / 대한산부인과학회잡지

OBJECTIVES: The purpose of this study was to get the clinical significance of urinary ocncentration of epidermal growth factor (EGF) of the patients with benign and malignant gynecologic tumors comparked to normal conterol group. METHODS: We studied the urinary EGF levels in 73 patients with gynecologic tumors at MIn-joong General Hospital of konkuk univ. the colleted samples were treated by radioimmnunoassay thechnique. chi-square analysis and STudent's t-test were used. significance was determined at the level of p < 0.05. RESULT: in 73 cases, benign gynecologic tumors were 54cases and gynecologic cancer were 19case (cervical cancer 8, ovarian cancer 8, other gynecologic cancer 3). the old in gynecologic cancers. The mean urinary EGF levels of the patients with benign gynlogic cancers. The mean urinary EGF levels of the patients with bengin gynecologic tumors was 16.4 +/- 6.6ng/mg. creatinie, and 16.1 +/- 4.7ng/mg. creatinine in gynecologic cancers (15.3 +/- 4.3ng/mg. creatinine in cervical cancer, 16.4 +/- 3.7ng/mg. cretinine in ovarian cancer), 16.7 +/- 3.7ng/mg. creatinine in normal control grop. There was no sinificant difference in urinary EGF levels between control group and the patients with gynecologic tumors. There was no significant difference in urinary EGF levels between benign gynecologic tumors and gynecologic cancers. CONCLUSION: Our data suggest that urinary EGF may not be useful as a marker of gynecologic turmor.

Clinical significance of Urinary Epidermal Growth Factor in Gynecologic Tumors / 대한산부인과학회잡지

OBJECTIVES: The purpose of this study was to get the clinical significance of urinary ocncentration of epidermal growth factor (EGF) of the patients with benign and malignant gynecologic tumors comparked to normal conterol group. METHODS: We studied the urinary EGF levels in 73 patients with gynecologic tumors at MIn-joong General Hospital of konkuk univ. the colleted samples were treated by radioimmnunoassay thechnique. chi-square analysis and STudent's t-test were used. significance was determined at the level of p < 0.05. RESULT: in 73 cases, benign gynecologic tumors were 54cases and gynecologic cancer were 19case (cervical cancer 8, ovarian cancer 8, other gynecologic cancer 3). the old in gynecologic cancers. The mean urinary EGF levels of the patients with benign gynlogic cancers. The mean urinary EGF levels of the patients with bengin gynecologic tumors was 16.4 +/- 6.6ng/mg. creatinie, and 16.1 +/- 4.7ng/mg. creatinine in gynecologic cancers (15.3 +/- 4.3ng/mg. creatinine in cervical cancer, 16.4 +/- 3.7ng/mg. cretinine in ovarian cancer), 16.7 +/- 3.7ng/mg. creatinine in normal control grop. There was no sinificant difference in urinary EGF levels between control group and the patients with gynecologic tumors. There was no significant difference in urinary EGF levels between benign gynecologic tumors and gynecologic cancers. CONCLUSION: Our data suggest that urinary EGF may not be useful as a marker of gynecologic turmor.